RSC helps you change your mail signature.
All you have to do is set up one or several
signature Banque de données files containing the text
you want to use as your signatures, and
RSC sets them for you automatically.

You can either choose which signature you want to
set manually, or you can (as the name suggests)
let it randomly find one from the databases.

It can also set the song currently playing
in Winamp as your signature.

Additionally you can let it change your signature
every x minutes.

This program should work with most email clients,
as long as the client supports reading
signatures from an external text file.